Background: Psoriasis is atchronic and recurrent disease that affects the skin, joints, and nails,
characterised as an immune-mediated disorder with systemic involvement.tThis can lead to
changes in the haemotological parameters as well. The tpsoriasis area and severity index (PASI)
is a tool that assesses the severity of psoriasis lesions and the therapeutic response of the
patients.tVarious studies have shown correlation between the PASI and haematological
parameters.
Aim: To assess the haematological parameters- platelet-lymphocyte ratio (PLR), platelet
distribution width (PDW), neutrophil-lymphocyte ratio (NLR), red cell distribution width
(RDW), mean platelet volume (MPV) and plataelet count (PLT) in psoriasis patients. These
values will also be correlated with the disease severity.
Materials and methods: A cross-sectional case-control study was conducted from May 2023
to January 2025 on 260 psoriasis patients and controls. The study was done at thetDepartment
of
Dermatology, Shri BM Patil Medical College Hospital and Research Center,
Vijayapura.tComplete hemogram was done for all the study participants and the parameters
were correlated with PASI in the cases. Additionally, the parameters were compared with that
of controls.
Results: PLT and NLR (p =0.045 and p =0.002 respectively) had a“statistically significant
positive correlation”with PASI. On comparison of cases to controls, a statistically significant
elevation was seen in the MPV (p =0.012 ) and NLR (p =0.012) in cases.
Conclusion: NLR, PLT and MPV can be used as cost-effective and affordable laboratory
markers in the assessment of disease severity in psoriasis, in conjunction with PASI (NLR,
PLT).
Publication Date: 2026-06-20